Novel Strategy for Alzheimer’s Disease Treatment through Oral Vaccine Therapy with Amyloid Beta

Alzheimer’s disease (AD) is a neuropathology characterized by progressive cognitive impairment and dementia. The attributed to senile plaques, which are aggregates of amyloid beta (Aβ) outside nerve cells; neurofibrillary tangles, filamentous accumulations phosphorylated tau in loss neurons the brain tissue. Immunization an AD mouse model with Aβ-eliminated pre-existing plaque amyloids prevented new accumulation. Furthermore, its effect showed that function can be improved passive immunity without side effects, such as lymphocyte infiltration mice treated vaccine therapy, indicating possibility therapy for AD. Further, considering effects due direct administration Aβ, practical use safe oral vaccine, expressed Aβ plants, expected. Indeed, this reduced accumulation brain. Moreover, almost no expression inflammatory IgG was observed. Therefore, vaccination prior or at early stage may prevent from causing